protein

Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His)

HY-P71642

5 μg;10 μg;50 μg

185;315;660 USD

Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His)

proteins

E. coli

5 μg;10 μg;50 μg

185;315;660 USD

Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His) is an enzyme that converts acetate to acetyl-CoA, which supplies acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed conditions.

Mouse

Acetyl-CoA synthetase 2 (ACSS2), an enzyme that converts acetate to acetyl-CoA, imparts a competitive growth advantage under conditions of metabolic stress by enhancing the ability of cancer cells to use acetate as an additional nutritional source when other carbon sources are scarce or cannot be used to sustain lipid biomass production. The activity of ACSS2 contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. The downregulation of ACSS2 expression is a metabolic hallmark of tumor progression and aggressive behavior in colorectal carcinoma [1] [2] .

Acss2; Acas2; Acecs1Acetyl-coenzyme A synthetase; cytoplasmic; EC 6.2.1.1; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.