protein

IFIH1 Protein, Human (His)

HY-P71641

5 μg;10 μg;50 μg

120;204;570 USD

IFIH1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

120;204;570 USD

The IFIH1 protein is an innate immune receptor that detects viral nucleic acids and triggers an antiviral response. IFIH1 is critical for type I interferon induction and recognizes ligands such as mRNA lacking 2'-O-methylation and long double-stranded RNA. IFIH1 Protein, Human (His) is the recombinant human-derived IFIH1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IFIH1 Protein, Human (His) is 326 a.a., with molecular weight of ~41.5 kDa.

Human

IFIH1 protein, as an innate immune receptor, functions as a cytoplasmic sensor for viral nucleic acids, playing a pivotal role in detecting viral infections and initiating a cascade of antiviral responses. It is essential for inducing type I interferons and pro-inflammatory cytokines in response to viral stimuli. IFIH1 recognizes ligands such as mRNA lacking 2'-O-methylation at their 5' cap and long double-stranded RNA (>1 kb). Upon ligand binding, it associates with mitochondria antiviral signaling protein (MAVS/IPS1), activating the IKK-related kinases TBK1 and IKBKE, which phosphorylate interferon regulatory factors (IRF3 and IRF7), leading to the transcription of antiviral immunological genes, including interferons IFN-alpha and IFN-beta. The protein is responsible for detecting various viruses, including members of the Picornaviridae family, such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), rhinovirus, and SARS-CoV-2. IFIH1 is also involved in antiviral signaling against viruses with a double-stranded DNA genome, like vaccinia virus. Furthermore, it contributes to innate immune signaling amplification by recognizing RNA metabolites generated during virus infection by ribonuclease L (RNase L). Additionally, IFIH1 may enhance natural killer cell function and participate in growth inhibition and apoptosis in various tumor cell lines.

CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140kDa; DEAD/H (Asp Glu Ala Asp/His) box polypeptide; DEAD/H box polypeptide; Helicard; Helicase with 2 CARD domains; Hlcd; MDA-5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

Room temperature in continental US; may vary elsewhere.