protein

Staphopain B Protein, S. aureus (GST)

HY-P71624

5 μg;10 μg;20 μg;50 μg

150;260;410;780 USD

Staphopain B Protein, S. aureus (GST)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg

150;260;410;780 USD

Staphopain B is a cysteine protease that severely disrupts host immunity by degrading elastin, fibrin, fibronectin, and kininogen. It blocks phagocytosis of opsonized Staphylococcus aureus and induces neutrophil and monocyte death through proteolytic activity. Staphopain B Protein, S. aureus (GST) is the recombinant Staphylococcus aureus-derived Staphopain B protein, expressed by E. coli , with N-GST labeled tag.

Staphylococcus aureus

Staphopain B, a cysteine protease, assumes a pivotal role in undermining the host innate immune response by targeting various host proteins. It exhibits the ability to degrade host elastin, fibrogen, fibronectin, and kininogen. Furthermore, Staphopain B interferes with the host's defense mechanisms by impeding the phagocytosis of opsonized S. aureus through the induction of death in neutrophils and monocytes in a proteolytic activity-dependent manner. This inhibition extends to the downregulation of the 'don't eat me' signal CD31 on neutrophils. Additionally, Staphopain B cleaves host galectin-3/LGALS3, thereby thwarting the neutrophil-activating capabilities of this lectin. Notably, the premature activation/folding of Staphopain B can be regulated by staphostatin B (SspC), which likely serves a protective role by preventing the degradation of staphylococcal cytoplasmic proteins by SspB.

sspB; SAV1047; Staphopain B; EC 3.4.22.-; Staphylococcal cysteine proteinase B; Staphylopain B

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.