protein

PDGF-DD Protein, Mouse (His-SUMO)

HY-P71615

20 μg;50 μg

230;505 USD

PDGF-DD Protein, Mouse (His-SUMO)

proteins

E. coli

20 μg;50 μg

230;505 USD

PDGF-DD protein is an important growth factor that controls embryonic development, cell proliferation, migration, survival and chemotaxis, and has a potent mitogenic effect on mesenchymal cells. It plays a key role in wound healing and has carcinogenic potential, contributing to tumor formation. PDGF-DD Protein, Mouse (His-SUMO) is the recombinant mouse-derived PDGF-DD protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Mouse

PDGF-DD Protein emerges as a crucial growth factor governing embryonic development, cell proliferation, migration, survival, and chemotaxis. Renowned for its potent mitogenic effects on mesenchymal cells, PDGF-DD assumes a pivotal role in wound healing and, intriguingly, harbors oncogenic potential capable of inducing tumor formation. Its influence extends to the intricate orchestration of events during angiogenesis, promoting macrophage recruitment, heightened interstitial pressure, and blood vessel maturation. PDGF-DD's involvement is notable in the initiation of processes leading to mesangial proliferative glomerulonephritis, marked by monocyte and macrophage influx, as well as extracellular matrix production. Structurally, PDGF-DD exists as a homodimer linked by disulfide bonds, engaging in interactions with PDGFRB homodimers and heterodimers formed by PDGFRA and PDGFRB, contributing to its versatile regulatory mechanisms.

Pdgfd; Scdgfb; Platelet-derived growth factor D; PDGF-D; Spinal cord-derived growth factor B; SCDGF-B

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.