protein

cGAS Protein, Human (His-SUMO)

HY-P71597

5 μg;10 μg;50 μg;100 μg

59;100;280;475 USD

cGAS Protein, Human (His-SUMO)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

59;100;280;475 USD

The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His-SUMO) is the recombinant human-derived cGAS protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Human

cGAS Protein, a nucleotidyltransferase, plays a pivotal role in innate immunity by catalyzing the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP. Acting as a key DNA sensor, cGAS directly binds double-stranded DNA (dsDNA), inducing the synthesis of 2',3'-cGAMP, a second messenger that activates STING1, leading to the production of type-I interferon and triggering immune responses. Recognizing curved long dsDNAs, cGAS acts as a foreign DNA sensor, detecting the presence of DNA from viruses, retroviruses, bacteria, and neutrophil extracellular traps (NETs). Moreover, cGAS responds to endogenous DNA released during cellular stress, contributing to sterile inflammation. It regulates cellular senescence by binding to cytosolic chromatin fragments and participates in the inflammatory response to genome instability and double-stranded DNA breaks. cGAS is also implicated in sensing translation stress, and its activation inhibits homologous recombination repair in response to DNA damage. Human cGAS exhibits species-specific mechanisms of DNA recognition, allowing a more finely tuned response to pathogens.

C6orf150; cGAMP synthase; cGAS; CGAS_HUMAN; cGMP Synthase; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μ m sterile filtered 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0 or PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.