protein

ALKAL1 Protein, Human (His, B2M)

HY-P71584

5 μg;10 μg;50 μg

140;250;600 USD

ALKAL1 Protein, Human (His, B2M)

proteins

E. coli

5 μg;10 μg;50 μg

140;250;600 USD

ALKAL1 Protein, Human (His, B2M) is a potent activating ligand for human ALK that binds to the extracellular domain of ALK.

Human

ALK and LTK ligand 1 (ALKAL1) also named “augmentor-β” or “FAM150A” is identified as a potent activating ligand for human ALK that bind to the extracellular domain of ALK. ALKAL1 is upregulated in colorectal cancer tissues and cell lines. Upregulation of ALKAL1 correlated with tumor malignancy and poor prognosis in colorectal cancer. ALKAL1 silencing inhibited tumorigenesis, metastasis and invasion of colorectal cancer cells, and inhibits SHH signaling pathway, which is essential for ALKAL1 induced migration. These findings reveal a new mechanism by which ALKAL1 participates in colorectal cancer migration and invasion via activating the SHH signaling pathway [1] .

ALKAL1; FAM150A; UNQ9433/PRO34745ALK and LTK ligand 1; Augmentor beta; AUG-beta; Protein FAM150A

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.