protein

METRNL/Meteorin-like Protein, Human (His-SUMO)

HY-P71569

5 μg;10 μg;20 μg;50 μg;100 μg

105;165;260;500;800 USD

METRNL/Meteorin-like Protein, Human (His-SUMO)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg;100 μg

105;165;260;500;800 USD

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Human

METRNL/Meteorin-like protein is induced in response to hormonal changes triggered by exercise or exposure to cold, contributing to enhanced energy expenditure. Its expression is observed in skeletal muscle post-exercise and adipose tissue during cold exposure, and it circulates in the bloodstream. METRNL/Meteorin-like protein facilitates energy expenditure by promoting the browning of white fat depots and improving glucose tolerance. Interestingly, its thermogenic effects are not directly exerted on adipocytes but involve the stimulation of various immune cell subtypes. It induces an eosinophil-dependent increase in IL4 expression and facilitates the alternative activation of adipose tissue macrophages, crucial for the enhanced expression of thermogenic and anti-inflammatory gene programs in fat. METRNL/Meteorin-like protein is essential for certain cold-induced thermogenic responses, highlighting its role in metabolic adaptations to low temperatures.

Meteorin like glial cell differentiation regulator; Meteorin; glial cell differentiation regulator like; Meteorin-like protein; METRL_HUMAN; Metrnl

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.