protein

AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO)

HY-P71566

20 μg;50 μg

360;790 USD

AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO)

proteins

E. coli

20 μg;50 μg

360;790 USD

AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) plays a critical role in regulating adipogenesis, and the proinflammation process in macrophages, including macrophage cholesterol homeostasis, foam cell formation and the development of atherosclerosis [1] [2] .

Mouse

AEBP1 acts as a transcriptional repressor that impedes macrophage cholesterol efflux, promoting foam cell formation, via PPARgamma1 and LXRalpha down-regulation [1] . Silencing AEBP1 markedly suppresses the proliferation, migration, invasion, metastasis and epithelial-mesenchymal transition of GC cells. Moreover, we demonstrats that knockdown of AEBP1 in GC cells leads to inhibition of the NF-κB pathway by hampering the degradation of IκBα [2] .

Aebp1; Aclp; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.