protein

Complement C3/C3a Protein, Bovine (His-SUMO)

HY-P71552

20 μg;50 μg

260;500 USD

Complement C3/C3a Protein, Bovine (His-SUMO)

proteins

E. coli

20 μg;50 μg

260;500 USD

Complement C3/C3a proteins play a key role in initiating the complement system, serving as substrates for C3 convertase in both the classical and alternative pathways. Upon activation, C3 undergoes proteolytic cleavage, yielding C3b, which is covalently bound to surface or immune aggregates. Complement C3/C3a Protein, Bovine (His-SUMO) is the recombinant bovine-derived Complement C3/C3a protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

Bovine

C3 assumes a pivotal role in the initiation of the complement system, serving as a substrate for C3 convertase in both the classical and alternative pathways. Upon activation, C3 undergoes proteolytic cleavage, generating C3b, which can covalently bind to cell surface carbohydrates or immune aggregates through its reactive thioester moiety. Concurrently, the anaphylatoxin C3a is produced as a result of C3 degradation, functioning as a mediator in local inflammatory processes. C3a induces smooth muscle contraction, enhances vascular permeability, and stimulates histamine release from mast cells and basophilic leukocytes. Additionally, in chronic inflammation, C3a acts as a chemoattractant for neutrophils.

C3Complement C3; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.