protein

CRMP1 Protein, Human

HY-P71547

5 μg;10 μg;50 μg

155;264;739 USD

CRMP1 Protein, Human

proteins

E. coli

5 μg;10 μg;50 μg

155;264;739 USD

The CRMP1 protein is indispensable for class 3 semaphorin-mediated signaling that drives cytoskeletal remodeling critical for axonal guidance. CRMP1 downstream of SEMA3A induces FLNA dissociation from F-actin, promoting actin cytoskeleton reorganization and growth cone collapse. CRMP1 Protein, Human is the recombinant human-derived CRMP1 protein, expressed by E. coli , with tag free. The total length of CRMP1 Protein, Human is 572 a.a., with molecular weight of ~62.2 kDa.

Human

CRMP1 protein is essential for signaling mediated by class 3 semaphorins, playing a crucial role in the subsequent remodeling of the cytoskeleton. It actively participates in axon guidance, acting downstream of SEMA3A to induce the dissociation of FLNA from F-actin, leading to a reorganization of the actin cytoskeleton and the subsequent collapse of the growth cone. Beyond its role in axon guidance, CRMP1 is implicated in invasive growth and cell migration processes, suggesting its involvement in cellular dynamics. Additionally, there is evidence suggesting its potential contribution to cytokinesis. CRMP1 forms homotetramers and heterotetramers with DPYSL2, DPYSL3, DPYSL4, or DPYSL5, indicating its association with related proteins. Furthermore, it interacts with PLXNA1 and FLNA, specifically through FLNA's calponin-homology (CH) domain 1 and filamin repeat 24, altering FLNA's ternary structure and promoting its dissociation from F-actin, highlighting its intricate involvement in cytoskeletal dynamics.

Collapsin response mediator protein 1; CRMP 1; CRMP-1; Crmp1; Dihydropyrimidinase like 1; Dihydropyrimidinase related protein 1; Dihydropyrimidinase-related protein 1; DPYL1_HUMAN; DPYSL1; DRP 1; DRP-1; DRP1; ULIP-3; Ulip3; Unc-33-like phosphoprotein 3

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.