protein

DPYSL3 Protein, Human (His)

HY-P71546

20 μg;50 μg

210;400 USD

DPYSL3 Protein, Human (His)

proteins

E. coli

20 μg;50 μg

210;400 USD

The DPYSL3 protein plays a key role in class 3 semaphorin-triggered signaling, driving cytoskeletal remodeling that is critical for axon guidance, growth cone collapse, and cell migration. As a component of homo- and heterotetramers of CRMP1, DPYSL2, DPYSL4 or DPYSL5, it is intricately associated with related proteins, highlighting its involvement in complex cellular dynamics. DPYSL3 Protein, Human (His) is the recombinant human-derived DPYSL3 protein, expressed by E. coli , with N-His labeled tag. The total length of DPYSL3 Protein, Human (His) is 570 a.a., with molecular weight of ~66.0 kDa.

Human

DPYSL3 protein is indispensable for the signaling cascades initiated by class 3 semaphorins and the subsequent remodeling of the cytoskeleton. It actively contributes to axon guidance, neuronal growth cone collapse, and cell migration, underlining its multifaceted role in cellular processes. As part of homotetramers and heterotetramers with CRMP1, DPYSL2, DPYSL4, or DPYSL5, it forms intricate associations with related proteins, reflecting its involvement in complex cellular dynamics. Additionally, DPYSL3 interacts with synaptic vesicle protein 2 and the SH3A domain of intersectin, further highlighting its participation in molecular interactions crucial for cellular functions. Notably, DPYSL3 engages with FLNA, as demonstrated in its interaction with FLNA's calponin-homology (CH) domain 1 and filamin repeat 24, emphasizing its role in cytoskeletal rearrangements mediated by FLNA.

Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP-4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; Dihydropyrimidinase-related protein 3; DPYL3_HUMAN; DPYSL3; DRP 3; DRP-3; DRP3; LCRMP; TUC4; ULIP 1; ULIP; ULIP-1; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein; Unc-33-like phosphoprotein 1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.