protein

AlkB Protein, E.coli (Myc, His-SUMO)

HY-P71479

5 μg;10 μg;50 μg;100 μg

75;125;350;560 USD

AlkB Protein, E.coli (Myc, His-SUMO)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

75;125;350;560 USD

AlkB Protein, E.coli (Myc, His-SUMO) is a protein found in E. coli, plays a major role in oxidative dealkylation processes.

E.coli

Iron-dependent dioxygenases of the AlkB protein family found in most organisms throughout the tree of life play a major role in oxidative dealkylation processes. In higher eukaryotes including yeast, plants and mammals, members of the AlkB family play pivotal roles. In humans, this family draws particular interest because of its involvement in DNA repair and progression of cancer, as they are frequently overexpressed in tumors and counteract the effects of alkylating drugs such as temozolamide used in chemotherapy. The alkylation-sensitive phenotype of E. coli alkB mutants marks the alkB pathway as an extremely effective defense mechanism against the cytotoxic effects of the SN2, but not the SN1, alkylating agents [1] [2] .

alkB; aidD; b2212; JW2200Alpha-ketoglutarate-dependent dioxygenase AlkB; EC 1.14.11.33; Alkylated DNA repair protein AlkB; DNA oxidative demethylase AlkB

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0 or10 mM Tris-HCl, 1 mM EDTA, pH 8.0.

Room temperature in continental US; may vary elsewhere.