protein

Endothelin-1/EDN1 Protein, Rat (His-KSI)

HY-P71446

5 μg;10 μg;20 μg;50 μg;100 μg

140;236;378;660;990 USD

Endothelin-1/EDN1 Protein, Rat (His-KSI)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg;100 μg

140;236;378;660;990 USD

Endothelin-1/Edn1 protein is an endothelium-derived vasoconstrictor peptide that plays a crucial role in vascular regulation.As a possible ligand of the G protein-coupled receptors EDNRA and EDNRB, it initiates a signaling cascade involving PTK2B, BCAR1, BCAR3 and the GTPases RAP1 and RHOA in glomerular mesangial cells, helping to regulate vascular tone.Endothelin-1/EDN1 Protein, Rat (His-KSI) is the recombinant rat-derived Endothelin-1/EDN1 protein, expressed by E.coli , with N-6*His, N-KSI labeled tag.

Rat

Endothelin-1 (Edn1) is a vasoconstrictor peptide derived from endothelial cells, acting through G-protein coupled receptors EDNRA and EDNRB. It likely functions as a ligand for these receptors, activating downstream signaling cascades involving PTK2B, BCAR1, BCAR3, and GTPases RAP1 and RHOA in glomerular mesangial cells. Furthermore, Endothelin-1 binds to the DEAR/FBXW7-AS1 receptor. This intricate interaction highlights its role in mediating various cellular responses, particularly in the regulation of vascular tone and mesangial cell function. The multifaceted actions of Endothelin-1 underscore its significance in vascular physiology and suggest its involvement in diverse cellular processes (

Edn1; Endothelin-1; ET-1; Preproendothelin-1; PPET1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.