protein

UBE2T Protein, Human (His)

HY-P71409

10 μg;50 μg

30;72 USD

UBE2T Protein, Human (His)

proteins

E. coli

10 μg;50 μg

30;72 USD

UBE2T protein is an important ubiquitination component. As an E2 ubiquitin-conjugating enzyme, it accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to proteins. This multifaceted enzyme catalyzes monoubiquitination, which is critical during MMC-induced DNA repair. UBE2T Protein, Human (His) is the recombinant human-derived UBE2T protein, expressed by E. coli , with N-6*His labeled tag. The total length of UBE2T Protein, Human (His) is 197 a.a., with molecular weight of 25-30 kDa.

Human

UBE2T, an essential component of the ubiquitination machinery, serves as an E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. This multifaceted enzyme demonstrates the ability to catalyze monoubiquitination, playing a crucial role in mitomycin-C (MMC)-induced DNA repair processes. UBE2T's significance is underscored by its specific association with the Fanconi anemia complex, where it collaborates with the E3 ubiquitin-protein ligase FANCL to catalyze monoubiquitination of FANCD2—an integral step in the DNA damage response pathway. Beyond its role in DNA repair, UBE2T exhibits versatility by mediating monoubiquitination of FANCL and FANCI and potentially contributing to the ubiquitination and degradation of BRCA1. Moreover, in vitro studies reveal UBE2T's capacity to promote various types of polyubiquitination, showcasing its involvement in diverse ubiquitin-dependent processes.

Ubiquitin-Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; UBE2T

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150mM NaCl, 2 mM DTT, 10% Glycerol, pH 7.5.

Shipping with dry ice