protein

SUMF1 Protein, Human (HEK293, His)

HY-P71345

10 μg;50 μg

110;310 USD

SUMF1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

110;310 USD

The SUMF1 protein plays an important role as an oxidase that converts cysteine to 3-oxoalanine on specific target proteins such as GALNS, ARSA, STS, and ARSE. This enzymatic activity is essential for the maturation of arylsulfatase and alkaline phosphatase, leading to the formation of 3-oxoalanine (fGly). SUMF1 Protein, Human (HEK293, His) is the recombinant human-derived SUMF1 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

SUMF1 Protein functions as an oxidase, facilitating the conversion of cysteine to 3-oxoalanine on specific target proteins, a process involving molecular oxygen and an unidentified reducing agent. This enzymatic activity is crucial for the maturation of arylsulfatases and some alkaline phosphatases, leading to the formation of 3-oxoalanine, also known as formylglycine (fGly). Notable substrates for SUMF1 include GALNS, ARSA, STS, and ARSE, highlighting its role in the modification of key proteins involved in various biological processes.

Sulfatase-Modifying Factor 1; C-Alpha-Formylglycine-Generating Enzyme 1; SUMF1; FGE

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 2 mM CaCl 2 , 10% Glycerol, pH 7.5.

Shipping with dry ice