protein

SORD Protein, Human (HEK293, His)

HY-P71328

10 μg;50 μg

170;510 USD

SORD Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

170;510 USD

SORD Protein is an enzyme that in humans is encoded by the SORD gene. SPRD is a polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. SPRD is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. SORD Protein, Human (HEK293, His) is the recombinant human-derived SORD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SORD Protein, Human (HEK293, His) is 356 a.a., with molecular weight of 39 kDa.

Human

Sorbitol dehydrogenase (SPRD) is an enzyme that in humans is encoded by the SORD gene. SPRD is a polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols, which is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. SPRD is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. SPRD may play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. SPRD may have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol [1] [2] [3] [4] .

Sorbitol Dehydrogenase; L-Iditol 2-Dehydrogenase; SORD

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.2 M NaCl, 5 mM DTT, 20% Glycerol, pH 8.0.

Shipping with dry ice.