protein

Siglec-E Protein, Mouse (HEK293, Fc)

HY-P71314

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

75;115;300;480;1350;2150 USD

Siglec-E Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

75;115;300;480;1350;2150 USD

Siglec-E Protein is a mouse orthologue of human Siglec-9 and functions as a key immunosuppressive checkpoint molecule. Siglec-E interacts with CD36 to inhibits downstream VAV signaling involved in modified LDL uptake, thereby delaying atherosclerosis. The endogenous inducible Siglec-E plays crucial anti-inflammatory and neuroprotective roles following ischemic stroke. Siglec-E Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-E protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-E Protein, Mouse (HEK293, Fc) is 336 a.a.

Mouse

Sialic acid binding Ig-like lectin E (Siglec-E) is a mouse orthologue of human Siglec-9 and functions as a key immunosuppressive checkpoint molecule. Siglec-E is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2-domain containing protein tyrosine phosphatase SHP-1/2 upon binding to its sialoglycan ligands. Siglec-E interacts with CD36 to inhibits downstream VAV signaling involved in modified LDL uptake, thereby delaying atherosclerosis. The endogenous inducible Siglec-E plays crucial anti-inflammatory and neuroprotective roles following ischemic stroke, and thus might underlie an intrinsic mechanism of resolution of inflammation and self-repair in the brain. Siglec-E is an important negative regulator of neutrophil recruitment to the lung and β2 integrin-dependent signaling and suppresses CD11b β2-integrin-dependent signaling [1] [2] [3] .

SiglecE; Siglec-E; Sialic Acid Binding Ig-like Lectin E

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.5 or PBS, pH 6.5.

Room temperature in continental US; may vary elsewhere.