protein

Siglec-7 Protein, Human (HEK293, His)

HY-P71311

10 μg;50 μg

185;520 USD

Siglec-7 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

185;520 USD

Siglec-7 protein is a putative adhesion molecule that mediates sialic acid-dependent cell binding with preference for α-2,3- and α-2,6-linked sialic acids.It interacts with disialoganglioside and may be masked by cis interactions.Siglec-7 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-7 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Siglec-7 protein, identified as a putative adhesion molecule, serves as a mediator of sialic-acid dependent cellular binding. It exhibits a preference for binding to alpha-2,3- and alpha-2,6-linked sialic acid, along with interactions with disialogangliosides such as disialogalactosyl globoside, disialyl lactotetraosylceramide, and disialyl GalNAc lactotetraoslylceramide. Notably, the sialic acid recognition site of Siglec-7 may undergo masking due to cis interactions with sialic acids on the same cell surface. In immune responses, it functions as an inhibitory receptor, inducing tyrosine phosphorylation upon ligand binding and recruiting cytoplasmic phosphatases through their SH2 domains, thereby blocking signal transduction and inhibiting natural killer cell cytotoxicity. Siglec-7 may also play a role in hemopoiesis, inhibiting the differentiation of CD34+ cell precursors towards the myelomonocytic cell lineage and impeding the proliferation of leukemic myeloid cells in vitro. Additionally, it interacts with PTPN6/SHP-1 upon phosphorylation.

Sialic acid-binding Ig-like lectin 7; AIRM-1; D-siglec; CD328; SIGLEC7

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.