protein

Serpin B1 Protein, Human (HEK293, His)

HY-P71303

10 μg;50 μg

120;360 USD

Serpin B1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

120;360 USD

Serpin B1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Serpin B1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44.0 kDa.

Human

The Serpin B1 protein, a neutrophil serine protease inhibitor, plays a crucial role in regulating the innate immune response, inflammation, and cellular homeostasis. Acting primarily to safeguard cells from proteases released in the cytoplasm during stress or infection, Serpin B1 protects against potential damage caused by the potent enzymes released from granules. It effectively regulates the activity of various neutrophil proteases, including elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Notably, Serpin B1 also serves as a potent intracellular inhibitor of GZMH, directly blocking its proteolytic activity. During inflammation, Serpin B1 limits the activity of inflammatory caspases (CASP1, CASP4, and CASP5) by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Moreover, when secreted, Serpin B1 promotes beta-cell proliferation through its protease inhibitory function. The protein functions as a monomer and interacts with CASP1, CASP4, CASP5, PRTN3, and GZMH, revealing its intricate role in modulating various cellular processes and interactions with key proteins in the immune and inflammatory pathways.

Leukocyte elastase inhibitor; SERPINB1; Monocyte/neutrophil elastase inhibitor; M/NEI; Peptidase inhibitor 2; PI-2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.