protein

BAFFR/TNFRSF13C Protein, Human

HY-P7130

10 μg;50 μg

90;190 USD

BAFFR/TNFRSF13C Protein, Human

proteins

E. coli

10 μg;50 μg

90;190 USD

377622267

BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation [1] . BAFFR/TNFRSF13C Protein, Human is a recombinant protein produced in E. coli.

Human

BAFF Receptor is expressed on all B cells (except plasma cells), including immature, transitional, mature, memory, and germinal center B cells, as well as on plasma cells [2] , while BAFF-R is also expressed on follicular helper T cells (TFH) [3] . The amino acid sequence of human BAFF Receptor protein has low homology for mouse and rat BAFF Receptor protein. BAFF Receptor binds to BAFF and recruits TNF receptor-associated factor 3 (TRAF-3) and TRAF-2 to the intracellular domain of BAFF-R molecules. The binding of TRAF3 to the BAFF-R reverses the inhibitory effect of unbound/cytoplasmic TRAF3 on the alternative NF-κB2 signaling pathway. It releases NF-κB-inducing kinase (NIK), which phosphorylates inhibitor of κB kinase 1 (IKK1) leading to activation of non-canonical NF-κB. BAFF-R signaling is critical for peripheral B cell survival and differentiation, germinal center formation, plasma cell survival, and IgG and IgE class switching [2] . BAFF Receptor binds to BAFF mediates B-cell survival, proliferation, and differentiation, and involves in the formation of GCs in secondary follicles in murine models and tertiary lymphoid structures in autoimmune diseases [3] . BAFF/BAFF-R signaling is crucial for primary B cell survival, differentiation and homeostasis [4] . A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice [5] .

rHuBAFF-R; CD268; TNFRSF13C; BR3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, pH 8.0, 500 mM NaCl.

Room temperature in continental US; may vary elsewhere.