protein

S100A12 Protein, Human

HY-P71270

10 μg

105 USD

S100A12 Protein, Human

proteins

E. coli

10 μg

105 USD

The S100A12 protein is a calcium, zinc, and copper binder that regulates inflammation and immune responses. As a DAMP molecule, it activates innate immune cells through AGER, triggering pro-inflammatory pathways. S100A12 Protein, Human is the recombinant human-derived S100A12 protein, expressed by E. coli , with tag free. The total length of S100A12 Protein, Human is 92 a.a., with molecular weight of ~11.0 kDa.

Human

S100A12, a calcium-, zinc-, and copper-binding protein, plays a pivotal role in regulating inflammatory processes and immune responses. Its pro-inflammatory functions include the recruitment of leukocytes, promotion of cytokine and chemokine production, and modulation of leukocyte adhesion and migration. Functioning as an alarmin or danger-associated molecular pattern (DAMP) molecule, S100A12 activates innate immune cells by binding to the receptor for advanced glycation end products (AGER). This binding triggers signaling pathways such as MAP-kinase and NF-kappa-B, resulting in the production of pro-inflammatory cytokines and the up-regulation of cell adhesion molecules like ICAM1 and VCAM1. Acting as a chemoattractant, it draws monocytes and mast cells to inflammatory sites, inducing degranulation and activation of mast cells. S100A12 also exhibits inhibitory effects on matrix metalloproteinases (MMP2, MMP3, and MMP9) by chelating Zn(2+) from their active sites. Additionally, it demonstrates filariacidal and filariastatic activities, along with antifungal properties against C.albicans and antibacterial effects against E.coli and P.aeruginosa. S100A12 forms homodimers and homooligomers (tetramers or hexamers) in the presence of calcium, zinc, and copper ions and interacts with AGER and CACYBP in a calcium-dependent manner.

Protein S100-A12; Calcium-binding protein in amniotic fluid 1; Calgranulin-C; Extracellular newly identified RAGE-binding protein; Migration inhibitory factor-related protein 6; S100 calcium-binding protein A12; Calcitermin; S100A12; CGRP; MRP-6; EN-RAGE

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.