protein

PDIA6 Protein, Human (HEK293, His)

HY-P71193

10 μg;50 μg

107;300 USD

PDIA6 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

107;300 USD

PDIA6 protein has molecular chaperone activity, which can inhibit the aggregation of misfolded proteins and contribute to quality control. It negatively regulates the unfolded protein response (UPR) by binding to ERN1 and inhibiting its signaling. PDIA6 Protein, Human (HEK293, His) is the recombinant human-derived PDIA6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA6 Protein, Human (HEK293, His) is 421 a.a., with molecular weight of ~52.0 kDa.

Human

The PDIA6 protein exhibits diverse functions, acting as a chaperone that inhibits the aggregation of misfolded proteins, thereby contributing to protein quality control. Moreover, it negatively regulates the unfolded protein response (UPR) by binding to UPR sensors like ERN1, leading to the inactivation of ERN1 signaling. Additionally, PDIA6 may modulate the UPR through the EIF2AK3 UPR sensor. Beyond its role in protein homeostasis, PDIA6 plays a significant role in platelet aggregation and activation induced by various agonists, such as convulxin, collagen, and thrombin. These multifaceted functions underscore the importance of PDIA6 in cellular processes related to protein folding, quality control, and platelet activation. Further research is needed to unravel the specific molecular mechanisms underlying these diverse functions, providing insights into the broader regulatory roles of PDIA6 in cellular physiology.

Protein Disulfide-Isomerase A6; Endoplasmic Reticulum Protein 5; ER Protein 5; ERp5; Protein Disulfide Isomerase P5; Thioredoxin Domain-Containing Protein 7; PDIA6; ERP5; P5; TXNDC7

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0.

Shipping with dry ice