protein

TGF beta 1/TGFB1 Protein, Rat/Mouse (HEK293)

HY-P7117

2 μg;10 μg;50 μg;100 μg;250 μg;500 μg

75;178;500;850;1350;1800 USD

TGF beta 1/TGFB1 Protein, Rat/Mouse (HEK293)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;250 μg;500 μg

75;178;500;850;1350;1800 USD

375588590

TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Mouse (HEK293) is a recombinant protein (A279-S390) produced by HEK293 cells [1] [2] .

Rat;Mouse

TGF beta 1/TGFB1 Protein (transforming growth factor beta 1) is a multifunctional cytokine, which is synthesized by almost all cells. TGF beta 1/TGFB1 Protein has a high ability to bind with TGFbRII [3] . The sequence of amino acids in TGFb1 proteins from different species is very stable, which leads to the conclusion that in the process of evolution, TGFb has been only slightly altered, and that both in humans and in animals, its function is similar. TGF beta 1/TGFB1 Protein is secreted as an inactive peptide, forming part of a ‘latent complex’ consisting of a mature TGFB1 dimer non-covalently bound to its latency-associated peptide (LAP) and, via LAP, to latent TGFB-binding proteins (LTBPs). Activated TGF beta 1/TGFB1 Protein binds to ubiquitously expressed cell-surface TGFB1 type I receptors (TGFBRI) and type II receptors (TGFBRII), which are transmembrane serine/threonine kinases [4] . TGF beta 1/TGFB1 Protein regulates cell proliferation, growth, differentiation and cells movement. TGFb1 has immunomodulatory effects. TGF beta 1/TGFB1 Protein has profibrogenic effects. TGF beta 1/TGFB1 Protein action can be local and systemic. TGF beta 1/TGFB1 Protein plays a driving role in development, fibrosis and cancer [4] .

rMuTGF-beta 1/TGFB1; Transforming growth factor beta-1; TGF-β1; LAP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 4mM HCL.

Room temperature in continental US; may vary elsewhere.