Nogo Receptor/NgR Protein, Mouse (HEK293, His) | MedChem Express LLC HY-P71158 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

Nogo Receptor/NgR Protein, Mouse (HEK293, His)

catalog :

HY-P71158

quantity :

10 μg;50 μg

price :

90;250 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P71158

Product Name :

Nogo Receptor/NgR Protein, Mouse (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

10 μg;50 μg

List Price :

90;250 USD

Product Description :

Nogo receptor/NgR proteins act as receptors for RTN4, OMG, MAG, and sialylated gangliosides. It also binds chondroitin sulfate proteoglycans and heparin. Nogo Receptor/NgR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Nogo Receptor/NgR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Nogo Receptor/NgR Protein, Mouse (HEK293, His) is 421 a.a., with molecular weight of 75-85 kDa.

SpeciesSummary :

Mouse

Background :

The Nogo Receptor/NgR Protein serves as a receptor for RTN4, OMG, and MAG, as well as for the sialylated gangliosides GT1b and GM1. Additionally, it functions as a receptor for chondroitin sulfate proteoglycans and can bind heparin. Intracellular signaling cascades are initiated through the coreceptor NGFR, leading to the activation of Rho and subsequent reorganization of the actin cytoskeleton. This signaling mechanism mediates axonal growth inhibition and plays a crucial role in regulating axon regeneration and neuronal plasticity within the adult central nervous system. Furthermore, Nogo Receptor/NgR is involved in postnatal brain development, playing a necessary role in axon migration across the brain midline and the formation of the corpus callosum. It also provides protection against apoptosis for motoneurons, potentially through interaction with MAG. Working in conjunction with RTN4 and LINGO1, it regulates neuronal precursor cell motility during cortical development. Like other family members, Nogo Receptor/NgR contributes to restricting the number of dendritic spines and synapses formed during brain development. It forms homodimers and interacts with various proteins, including MAG, RTN4, NGFR, LINGO1, and OLFM1, highlighting its multifaceted roles in cellular signaling and neural development.

ALTnames :

Reticulon-4 Receptor; Nogo Receptor; NgR; Nogo-66 Receptor; RTN4R; NOGOR

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage :

Room temperature in continental US;may vary elsewhere.

more info or order :

MedChem Express LLC product webpage