protein

TPO/Thrombopoietin Protein, Human (CHO, His)

HY-P7115

2 μg;5 μg;10 μg;50 μg

35;55;85;230 USD

TPO/Thrombopoietin Protein, Human (CHO, His)

proteins

CHO

2 μg;5 μg;10 μg;50 μg

35;55;85;230 USD

375588588

TPO/Thrombopoietin Protein, Human (CHO)，also called megakaryocyte growth and development factor, is a cytokine that regulates megakaryocyte and platelet production.

Human

Recombinant thrombopoietin reduced radiation- and chemotherapy-induced thrombocytopenia, enhanced platelet recovery after bone marrow transplantation and increased the number of megakaryocyte precursor cells in stem cell harvests. Injection of thrombopoietin into animals stimulates the number, size and ploidy of bone marrow megakaryocytes and increases the platelet count up to ten-fold [1] . Superphysiological amounts of Thrombopoietin/TPO (>100 ng/mL) are able to directly activate platelet aggregation in vitro . Thrombopoietin/TPO also has significant effects on platelet adhesion under flow. Low Thrombopoietin/TPO concentrations (001-1 ng/mL) accelerate firm platelet adhesion to von Willebrand factor and prevent de-attachment at higher flow rates [2] .

rHuThrombopoietin/TPO; TPO

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

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