protein

PRDX6 Protein, Human (His)

HY-P71145

10 μg;50 μg

170;510 USD

PRDX6 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

170;510 USD

The PRDX6 protein is a thiol-specific peroxidase that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols. PRDX6 Protein, Human (His) is the recombinant human-derived PRDX6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PRDX6 Protein, Human (His) is 224 a.a., with molecular weight of 30-33 kDa.

Human

PRDX6, a thiol-specific peroxidase, demonstrates a crucial role in cellular defense against oxidative stress by catalyzing the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols, respectively. This multifunctional enzyme exhibits the ability to reduce H(2)O(2) as well as short-chain organic, fatty acid, and phospholipid hydroperoxides. Additionally, PRDX6 possesses phospholipase activity, allowing it to either reduce the oxidized sn-2 fatty acyl group of phospholipids through peroxidase activity or hydrolyze the sn-2 ester bond of phospholipids through phospholipase activity. These functions are dependent on its binding to phospholipids at acidic pH and to oxidized phospholipids at cytosolic pH. Beyond its peroxidase activity, PRDX6 serves a critical role in phospholipid homeostasis and acts as an acyl-CoA-dependent lysophospholipid acyltransferase, facilitating the conversion of lysophosphatidylcholine (LPC) into phosphatidylcholine (PC). The enzyme exhibits a clear preference for LPC as the lysophospholipid and palmitoyl CoA as the fatty acyl substrate.

Peroxiredoxin-6; 1-Cys Peroxiredoxin; 1-Cys PRX; 24 kDa Protein; Acidic Calcium-Independent Phospholipase A2; aiPLA2; Antioxidant Protein 2; Liver 2D PAGE Spot 40; Non-Selenium Glutathione Peroxidase; NSGPx; Red Blood Cells Page Spot 12; PRDX6; AOP2; KIAA0106

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.