protein

Serpin B3 Protein, Human (HEK293, His)

HY-P71142

10 μg;50 μg

170;440 USD

Serpin B3 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

170;440 USD

The Serpin B3 protein exhibits versatility in cellular regulation and may act as a papain-like cysteine protease inhibitor to modulate immune responses against tumor cells. Its dual role extends to inhibiting UV-induced apoptosis by inhibiting c-Jun NH(2)-terminal kinase (JNK1) activity, suggesting that Serpin B3 is involved in the stress response. Serpin B3 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B3 Protein, Human (HEK293, His) is 390 a.a., with molecular weight of 41-50 kDa.

Human

The Serpin B3 protein emerges as a versatile participant in cellular regulation, potentially functioning as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Its dual role extends to the inhibition of UV-induced apoptosis, accomplished by suppressing the activity of c-Jun NH(2)-terminal kinase (JNK1), thereby implicating Serpin B3 in cellular processes related to stress response. The protein's interaction with MAPK8/JNK1 further underscores its intricate involvement in signaling pathways, highlighting its potential as a multifaceted regulator with implications for immune modulation and apoptosis regulation.

Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; Squamous cell carcinoma antigen 1; T4-A; SCCA1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 0.02% Tween80, 4% Mannitol, pH 7.4.

Room temperature in continental US; may vary elsewhere.