protein

SP-10/ACRV1 Protein, Human (HEK293, C-His)

HY-P71139

5 μg;10 μg;50 μg

53;85;250 USD

SP-10/ACRV1 Protein, Human (HEK293, C-His)

proteins

HEK293

5 μg;10 μg;50 μg

53;85;250 USD

SP-10/ACRV1 Protein is a testis-specific acrosomal matrix protein, which is evolutionarily conserved among mammals. The gene coding for the SP-10 protein, Acrv1, served as an outstanding model to understand the regulation of male germ-cell-specific gene transcription. The human and mouse SP-10 proteins share homology in the carboxyl terminal region, but contain distinct amino termini. SP-10 probably has an important role in human sperm function, is a promising contraceptive vaccine immunogen for humans, and can serve as a marker protein [1] [2] . SP-10/ACRV1 Protein, Human (HEK293, C-His) is the recombinant human-derived SP-10/ACRV1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SP-10/ACRV1 Protein, Human (HEK293, C-His) is 244 a.a., with molecular weight of ~35.0 kDa.

Human

SP-10 is an abundant protein present in both the acrosomal matrix as well as in the inner acrosomal membrane. The SP-10 antibody has been shown to be useful for staging the seminiferous cycle in the mouse and human [1] . A full-length 45-kDa SP-10 precursor protein is present in the testis and that SP-10 peptides of 32, 30, 28, and 26 kDa result from proteolytic processing of the SP-10 precursor protein in the testis and/or alternative splicing [2] .

Acrosomal Protein SP-10; Acrosomal Vesicle Protein 1; ACRV1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.