protein

WARS Protein, Human (His)

HY-P71134

10 μg;50 μg

100;280 USD

WARS Protein, Human (His)

proteins

E. coli

10 μg;50 μg

100;280 USD

WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (His) is the recombinant human-derived WARS protein, expressed by E. coli , with N-6*His labeled tag. The total length of WARS Protein, Human (His) is 471 a.a., with molecular weight of ~60.0 kDa.

Human

WARS, encompassing Isoform 1, Isoform 2, T1-TrpRS, and T2-TrpRS, displays aminoacylation activity, with T2-TrpRS being the exception as it lacks this enzymatic function. In terms of angiostatic activity, Isoform 2, T1-TrpRS, and T2-TrpRS exhibit this property, while Isoform 1 does not possess angiostatic capabilities. Particularly, T2-TrpRS stands out by inhibiting fluid shear stress-activated responses in endothelial cells. WARS plays a pivotal role in regulating key signaling pathways, including ERK, Akt, and eNOS activation, which are associated with angiogenesis, cytoskeletal reorganization, and the expression of genes responsive to shear stress. This multifaceted functionality underscores WARS's involvement in intricate cellular processes and its potential impact on vascular responses.

WARS also known as Tryptophanyl-tRNA synthetase; Interferon-induced protein 53.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 8% Trehalose, 4% Mannitol, 50 mM NaCl, 0.05% Tween 80, pH 7.5.

Room temperature in continental US;may vary elsewhere.