protein

NPR3 Protein, Human (HEK293, Fc)

HY-P71122

10 μg;50 μg

130;370 USD

NPR3 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

130;370 USD

NPR3 Protein, a receptor for natriuretic peptides, exhibits similar affinities for NPPA/ANP, NPPB/BNP, and NPPC/CNP. It regulates diuresis, blood pressure, and skeletal development, possibly serving as a clearance receptor for NPPA, NPPB, and NPPC. Despite lacking guanylate cyclase activity, NPR3 forms disulfide-linked homodimers and interacts with OSTN, indicating potential involvement in various physiological processes. NPR3 Protein, Human (HEK293, Fc) is the recombinant human-derived NPR3 protein, expressed by HEK293 , with C-hFc labeled tag.

Human

The NPR3 Protein serves as a receptor for the natriuretic peptide hormones, exhibiting similar affinities for atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. It is implicated in the regulation of diuresis, blood pressure, and skeletal development and may function as a clearance receptor for NPPA, NPPB, and NPPC, thereby modulating their local concentrations and effects. Despite lacking guanylate cyclase activity, NPR3 forms homodimers that are disulfide-linked, with additional dimerization possible through the C-terminal cysteine of isoform 2. The receptor also interacts with OSTN, suggesting potential involvement in diverse physiological processes.

ANP-C; ANPR-C; NPR3; NPRC; NPR-C; ANPRC; C5orf23

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.