protein

Serpin E1 Protein, Human (HEK293, His)

HY-P71077

5 μg;10 μg;50 μg;100 μg

68;115;320;545 USD

Serpin E1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

68;115;320;545 USD

Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Serpin E1, a serine protease inhibitor, exerts its regulatory influence on various cellular processes. It inhibits TMPRSS7 and serves as the primary inhibitor for both tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). In the context of fibrinolysis, Serpin E1 is crucial for down-regulating PLAT, contributing to the controlled degradation of blood clots. Simultaneously, as a PLAU inhibitor, it plays a role in modulating cell adhesion and spreading. Beyond its function as a protease inhibitor, Serpin E1 acts as a regulator of cell migration, impacting processes such as keratinocyte migration during cutaneous injury repair. Its involvement extends to cellular and replicative senescence, contributing to alveolar type 2 cell senescence in the lung. Furthermore, Serpin E1 participates in the regulation of cementogenic differentiation in periodontal ligament stem cells and influences odontoblast differentiation and dentin formation during odontogenesis. The protein engages in various interactions, forming a heterodimer with TMPRSS7 and interacting with multiple partners, including VTN, PPP1CB, PLAUR/uPAR, SORL1, and LRP1, among others, highlighting its multifaceted role in diverse cellular pathways.

Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.0 or 20 mM HAC-NaAC, 150 mM NaCl, pH 5.5.

Room temperature in continental US;may vary elsewhere.