protein

TDT Protein, Human (His)

HY-P71070

10 μg;50 μg

140;420 USD

TDT Protein, Human (His)

proteins

E. coli

10 μg;50 μg

140;420 USD

TDT protein, a template-independent DNA polymerase, non-specifically adds deoxynucleoside 5'-triphosphates to the 3'-end of a DNA initiator. It crucially contributes to in vivo processes, particularly adding nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during B- and T-cell maturation. TDT Protein, Human (His) is the recombinant human-derived TDT protein, expressed by E. coli , with N-6*His labeled tag. The total length of TDT Protein, Human (His) is 509 a.a., with molecular weight of ~62.0 kDa.

Human

The TDT protein is a template-independent DNA polymerase that carries out the non-specific addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of its important roles in vivo is adding nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation process of B- and T-cells.

DNA nucleotidylexotransferase; Terminal addition enzyme; Terminal deoxynucleotidyltr; Terminal deoxynucleotidyltransferase; Terminal transferase; DNTT; TDT

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 0.1 M KH 2 PO 4 , 200 mM KCl, 1 mM 2-Mercaptoethanol, 50% Glycerol, pH 7.2.

Shipping with dry ice.