protein

T-PA Protein, Human (HEK293, His)

HY-P71051

5 μg;10 μg;50 μg;100 μg

75;125;350;600 USD

T-PA Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

75;125;350;600 USD

T-PA is a key proteolytic enzyme that coordinates the conversion of the abundant but inactive zymogen plasminogen to its active form plasmin via hydrolysis of a single Arg-Val bond. This enzymatic conversion helps regulate plasmin-mediated proteolysis, a key process in tissue remodeling, degradation, and various pathophysiological events. T-PA Protein, Human (HEK293, His) is the recombinant human-derived T-PA protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Tissue plasminogen activator (t-PA) is a pivotal protein that catalyzes the conversion of the abundant, yet inactive, zymogen plasminogen into the active protease plasmin, achieved by hydrolyzing a single Arg-Val bond in plasminogen. This enzymatic process is integral in controlling plasmin-mediated proteolysis, thereby playing a crucial role in tissue remodeling, degradation, and cell migration, as well as influencing various physiopathological events. Furthermore, t-PA exhibits functional significance during oocyte activation, participating in the cortical granule reaction in the zona reaction, which contributes to the prevention of polyspermy and serves as a protective mechanism during fertilization (By similarity). The multifaceted roles of t-PA underscore its importance in both physiological and reproductive processes, emphasizing its regulatory functions in proteolysis and cellular events.

T-PA; TPA; t-plasminogen activator; Tissue plasminogen activator;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Succinate, 4% Trehalose, 4% Mannitol, 0.2 mM CaCl 2 ,0.02% Tween 80, pH 4.5 or 20 mM MES, 150 mM NaCl, pH 5.5 or 20 mM MES, 150 mM NaCl, pH 5.5.

Room temperature in continental US; may vary elsewhere.