protein

PPIH Protein, Human (His)

HY-P71029

10 μg;50 μg

150;450 USD

PPIH Protein, Human (His)

proteins

E. coli

10 μg;50 μg

150;450 USD

The PPIH protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of prolyl imide peptide bonds and may contribute to protein folding. It plays a crucial role in pre-mRNA splicing and contributes to the formation of the U4/U5/U6 tri-snRNP complex in spliceosome assembly. PPIH Protein, Human (His) is the recombinant human-derived PPIH protein, expressed by E. coli , with N-6*His labeled tag.

Human

PPIH Protein functions as a peptidyl-prolyl cis-trans isomerase (PPIase), facilitating the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and potentially aiding in protein folding. Beyond its role in protein folding, PPIH actively participates in pre-mRNA splicing, suggesting involvement in the intricate process of spliceosome assembly. Specifically, it may contribute to the formation of the U4/U5/U6 tri-snRNP complex, a fundamental component of the spliceosome. This multifunctional role implies that PPIH may act as a chaperone, highlighting its versatile involvement in both protein folding and the regulation of essential cellular processes related to mRNA splicing. Further exploration is warranted to elucidate the specific molecular mechanisms and cellular contexts through which PPIH exerts its functions in protein homeostasis and pre-mRNA splicing.

Peptidyl-Prolyl Cis-Trans Isomerase H; PPIase H; Rotamase H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; CypH; U-snRNP-Associated Cyclophilin SnuCyp-20; USA-CYP; PPIH; CYP20; CYPH

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice