protein

NRCAM Protein, Human (HEK293, Fc)

HY-P71002

10 μg;50 μg

93;260 USD

NRCAM Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

93;260 USD

Neuronal cell adhesion molecule (NRCAM) is a member of the immunoglobulin superfamily and a cell adhesion protein. NRCAM is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system while being crucial for the saltatory propagation of action potentials along myelinated axons. NRCAM also plays a general role in cell-cell communication. NRCAM Protein, Human (HEK293, Fc) is the recombinant human-derived NRCAM protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NRCAM Protein, Human (HEK293, Fc) is 576 a.a., with molecular weight of ~114.0 kDa.

Human

Neuronal cell adhesion molecule (NRCAM) is a member of the immunoglobulin superfamily and a cell adhesion protein with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. NRCAM is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth as a ankyrin-binding protein. NRCAM plays a role in mediating cell-cell contacts between Schwann cells and axons; the formation and maintenance of the nodes of Ranvier on myelinated axons; and normal clustering of sodium channels at heminodes. Therefore, NRCAM is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system while being crucial for the saltatory propagation of action potentials along myelinated axons. NRCAM is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of NRCAM have been associated with autism and addiction vulnerability [1] [2] [3] .

Neuronal cell adhesion molecule; Nr-CAM; Neuronal surface protein Bravo; hBravo; gCAM-related cell adhesion molecule; Ng-CAM-related; KIAA0343

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.