protein

Vasorin Protein, Human (552a.a, HEK293, His)

HY-P70999

10 μg;50 μg

120;360 USD

Vasorin Protein, Human (552a.a, HEK293, His)

proteins

HEK293

10 μg;50 μg

120;360 USD

Vasorin (VASN) is located in cell surface and extracellular exosome, and may act as an inhibitor of TGF-beta signaling and is involved in negative regulation of epithelial to mesenchymal transition. VASN is also involved in hypoxia and cellular response to redox state, augmenting Notch signaling under hypoxic stress, and expression of VASN is correlated with increased aggression of human gliomas. Vasorin Protein, Human (552a.a, HEK293, His) is the recombinant human-derived Vasorin protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Vasorin (VASN) is located in cell surface and extracellular exosome, containing tandem arrays of a characteristic leucine-rich repeat motif, an epidermal growth factor-like motif, and a fibronectin type III-like motif at the extracellular domain. VASN may act as an inhibitor of TGF-beta signaling and is involved in negative regulation of epithelial to mesenchymal transition. VASN is also involved in hypoxia and cellular response to redox state, as hypoxia preferentially augments Notch signaling in glioma stem-like cells by inducing VASN, the target gene of HIF1/STAT3. VASN functions as a competitive inhibitor of Numb to reduce Notch turnover, augmenting Notch signaling under hypoxic stress, and expression of VASN is correlated with increased aggression of human gliomas [1] [2] .

Vasorin; Protein Slit-Like 2; VASN; SLITL2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US;may vary elsewhere.