protein

Syndecan-2 Protein, Human (HEK293, His)

HY-P70995

10 μg;50 μg

80;240 USD

Syndecan-2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

80;240 USD

Syndecan-2 Protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Syndecan-2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 25-40 kDa.

Human

Syndecan-2 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Increased expression of Syndecan-2 may directly relate to loss of cell/substrate interactions and contact inhibition and contribute to both the tumorigenic and metastatic potential in cancer cells. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 is a novel marker of hematopoietic stem cell (HSC) that regulates HSC repopulating capacity through control of expression of Cdkn1c (p57) and HSC quiescence. In addition, Syndecan-2 inhibits α-SMA expression, cell contraction, proliferation, and migration induced by TGF-β1 in mouse lung fibroblasts [1] [2] [3] .

Syndecan-2; SYND2; Fibroglycan; Heparan Sulfate Proteoglycan Core Protein; HSPG; CD362; SDC2; HSPG1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-Citrate, 150 mM NaCl, pH 7.0.

Room temperature in continental US; may vary elsewhere.