protein

TPP1 Protein, Human (HEK293, His)

HY-P70980

10 μg;50 μg

160;450 USD

TPP1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

160;450 USD

TPP1, a lysosomal serine protease, acts as a non-specific lysosomal peptidase, displaying tripeptidyl-peptidase I activity in lysosomal protein degradation. Its function involves generating tripeptides from the breakdown products of other lysosomal proteinases, emphasizing its role in processing and hydrolyzing peptides within the lysosomal environment. Notably, TPP1 requires substrates with an unsubstituted N-terminus. TPP1 Protein, Human (HEK293, His) is the recombinant human-derived TPP1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TPP1 Protein, Human (HEK293, His) is 544 a.a., with molecular weight of ~78.75 kDa.

Human

TPP1, a lysosomal serine protease, exhibits tripeptidyl-peptidase I activity, as evidenced by its involvement in lysosomal protein degradation. While its precise substrate specificity is not yet fully elucidated, TPP1 is thought to function as a non-specific lysosomal peptidase, generating tripeptides from the breakdown products produced by other lysosomal proteinases. Notably, TPP1 requires substrates with an unsubstituted N-terminus, further highlighting its role in processing and hydrolyzing peptides within the lysosomal environment.

Tripeptidyl-Peptidase 1; TPP-1; Cell Growth-Inhibiting Gene 1 Protein; Lysosomal Pepstatin-Insensitive Protease; LPIC; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase I; TPP-I; TPP1; CLN2

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM CaCl 2 , 10% Glycerol, pH 7.5.

Shipping with dry ice.