protein

NRG1-beta 1 Protein, Human (246a.a, His)

HY-P70967

2 μg;10 μg;50 μg

35;60;180 USD

NRG1-beta 1 Protein, Human (246a.a, His)

proteins

E. coli

2 μg;10 μg;50 μg

35;60;180 USD

NRG1 is a direct ligand of the ERBB3 and ERBB4 tyrosine kinase receptors. NRG1 can induce the phosphorylation and activation of MAPK3/ERK1 , MAPK1/ERK2 and AKT1 . NRG1 can induce cell growth, differentiation and proliferation. NRG1-beta 1 Protein, Human (246a.a, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (246a.a, His) is 246 a.a., with molecular weight of ~35.0 kDa.

Human

Pro-neuregulin-1, membrane-bound isoform (NRG1) is a direct ligand of the ERBB3 and ERBB4 tyrosine kinase receptors. Several isomers of NRG1 can induce the growth and differentiation of epithelial cells, glial cells, neuronal cells and skeletal muscle cells. The induced expression of acetylcholine receptors in synaptic vesicles during the formation of neuromuscular junction stimulates the germination and lactation of breast lobular alveoli and induces the differentiation of breast tumor cells. Stimulate Schwann cell proliferation; It affects the development of the heart muscle. NRG1 is also a ligand for integrins and binds (via the EGF domain) the integrins ITGAV: ITGB3 or ITGA6:ITGB4. NRG1 can induce the phosphorylation and activation of MAPK3/ERK1 , MAPK1/ERK2 and AKT1 [1] [2] [3] [4] .

Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1 ECD; NRG1; GGF; HGL; HRGA; NDF; SMDF;

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 4 mM HCl or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

Room temperature in continental US; may vary elsewhere.