protein

Kininogen-1 Protein, Human (409a.a, HEK293, His)

HY-P70956

10 μg;50 μg

161;450 USD

Kininogen-1 Protein, Human (409a.a, HEK293, His)

proteins

HEK293

10 μg;50 μg

161;450 USD

Kininogen-1 is a key regulator in the coagulation process, inhibiting thiol proteases and strategically targeting prekallikrein and factor XI for coagulation regulation. HMW-kininogen prevents thrombin and plasmin-induced platelet aggregation and aids in hemostasis. Kininogen-1 Protein, Human (409a.a, HEK293, His) is the recombinant human-derived Kininogen-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Kininogen-1 Protein, Human (409a.a, HEK293, His) is 409 a.a., with molecular weight of ~63.0 kDa.

Human

Kininogen-1, a pivotal player in blood coagulation, functions as an inhibitor of thiol proteases. In this capacity, HMW-kininogen strategically positions prekallikrein and factor XI adjacent to factor XII, crucial for blood clotting regulation. HMW-kininogen actively prevents thrombin- and plasmin-induced thrombocyte aggregation, contributing to hemostasis. In contrast, LMW-kininogen is not involved in blood clotting but exerts inhibition on thrombocyte aggregation. The active peptide bradykinin, released from HMW-kininogen, manifests diverse physiological effects, including influencing smooth muscle contraction, inducing hypotension, promoting natriuresis and diuresis, reducing blood glucose levels, mediating inflammation through increased vascular permeability, stimulating nociceptors, and triggering the release of other inflammatory mediators like prostaglandins. Additionally, bradykinin exhibits a cardioprotective effect, acting directly and indirectly through endothelium-derived relaxing factor action. The multifaceted roles of kininogen-1 underscore its significance in orchestrating various physiological processes.

Kininogen-1; lpha-2-Thiol Proteinase Inhibitor; Fitzgerald Factor; High Molecular Weight Kininogen; HMWK; Williams-Fitzgerald-Flaujeac Factor; KNG1; BDK; KNG

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM HAc-NaAC, 150 mM NaCl, pH 4.0.

Room temperature in continental US; may vary elsewhere.