protein

GM2A Protein, Human (HEK293, His)

HY-P70954

10 μg;50 μg

160;450 USD

GM2A Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

160;450 USD

Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. GM2A catalyzes the degradation of the ganglioside GM2 as well as affects lipid storage and neuromuscular process controlling balance. GM2A Protein, Human (HEK293, His) is the recombinant human-derived GM2A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM2A Protein, Human (HEK293, His) is 162 a.a., with molecular weight of 19-22 kDa.

Human

Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. GM2A, together with beta-hexosaminidase A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in GM2A result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits calcium-independent phospholipase activity, cholesterol transfer activity as well as affects lipid storage and neuromuscular process controlling balance [1] [2] .

Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

Room temperature in continental US;may vary elsewhere.