IGF2BP2 Protein, Human (T7-His) | MedChem Express LLC HY-P70950 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

IGF2BP2 Protein, Human (T7-His)

catalog :

HY-P70950

quantity :

10 μg;50 μg

price :

170;510 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P70950

Product Name :

IGF2BP2 Protein, Human (T7-His)

Product Type :

proteins

Host Species :

E. coli

Size :

10 μg;50 μg

List Price :

170;510 USD

Product Description :

The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (T7-His) is the recombinant human-derived IGF2BP2 protein, expressed by E. coli , with N-T7, C-6*His labeled tag.

SpeciesSummary :

Human

Background :

The IGF2BP2 protein functions as an RNA-binding factor, orchestrating the recruitment of target transcripts into cytoplasmic protein-RNA complexes (mRNPs). This 'caging' of transcripts within mRNPs facilitates mRNA transport and transient storage while modulating the rate and location of target transcripts encountering the translational apparatus. Moreover, IGF2BP2 shields these transcripts from endonuclease attacks or degradation mediated by microRNAs. With a preference for N6-methyladenosine (m6A)-containing mRNAs, IGF2BP2 enhances their stability. It exhibits specific binding to the 5'-UTR of insulin-like growth factor 2 (IGF2) mRNAs and selectively binds to transcripts like beta-actin/ACTB and MYC, increasing MYC mRNA stability through interaction with the coding region instability determinant (CRD). IGF2BP2 can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner and interacts with various proteins, including HNRPD, IGF2BP1, ELAVL1, DHX9, HNRNPU, MATR3, and PABPC1. Its interaction with the HOXB-AS3 peptide further enhances MYC stability.

ALTnames :

Insulin-Like Growth Factor 2 mRNA-Binding Protein 2; IGF2 mRNA-Binding Protein 2; IMP-2; Hepatocellular Carcinoma Autoantigen p62; IGF-II mRNA-Binding Protein 2; VICKZ Family Member 2; IGF2BP2; IMP2; VICKZ2

Purity :

Greater than 90% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage :

Room temperature in continental US;may vary elsewhere.

more info or order :

MedChem Express LLC product webpage