protein

JAM-A/CD321 Protein, Human (HEK293, His)

HY-P70948

10 μg;50 μg

115;320 USD

JAM-A/CD321 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

115;320 USD

The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions, is present in early junction development, and recruits PARD3. Binding of the PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thereby impeding tight junction assembly. JAM-A/CD321 Protein, Human (HEK293, His) is the recombinant human-derived JAM-A/CD321 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

The JAM-A/CD321 protein appears to be involved in the formation of tight junctions in epithelial cells. It is present in the early stages of cell junction development and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction between PARD3 and JAM1, thus hindering tight junction assembly. The protein also plays a role in regulating monocyte transmigration, which is crucial for maintaining the integrity of the epithelial barrier. It acts as a ligand for integrin alpha-L/beta-2, facilitating the transmigration of memory T-cells and neutrophils. Additionally, it is involved in platelet activation. In terms of microbial infection, JAM-A/CD321 acts as a receptor for Mammalian reovirus sigma-1.

Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 100 mM Glycine, pH 7.5.

Room temperature in continental US;may vary elsewhere.