protein

FIS1 Protein, Human (His)

HY-P70941

10 μg;50 μg

90;250 USD

FIS1 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

90;250 USD

The FIS1 protein is essential for mitochondrial network fragmentation and perinuclear clustering. Although FIS1 plays a minor role in recruiting DNM1L to the mitochondrial surface, it is associated with fission. FIS1 Protein, Human (His) is the recombinant human-derived FIS1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FIS1 Protein, Human (His) is 122 a.a., with molecular weight of ~15.0 kDa.

Human

The FIS1 Protein plays a crucial role in the fragmentation of the mitochondrial network, contributing to its perinuclear clustering. While it has a minor role in recruiting and associating with the fission mediator dynamin-related protein 1 (DNM1L) on the mitochondrial surface, FIS1 is implicated in mitochondrial fission. Notably, it may not be essential for the assembly of functional fission complexes and subsequent membrane scission events. Beyond its involvement in mitochondrial dynamics, FIS1 also mediates peroxisomal fission, particularly when the outcomes of fission are directed towards mitochondrial homeostasis, mitophagy, or apoptosis. The protein can induce the release of cytochrome c from the mitochondrion to the cytosol, ultimately triggering apoptosis. Interactions with DNM1L/DLP1, MARCHF5, MIEF1, and PEX11A, PEX11B, PEX11G highlight the intricate network of associations that contribute to FIS1's multifaceted role at the interface of mitochondrial and peroxisomal dynamics.

Mitochondrial Fission 1 Protein; FIS1 Homolog; hFis1; Tetratricopeptide Repeat Protein 11; TPR Repeat Protein 11; FIS1; TTC11; CGI-135

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, pH 8.0.

Room temperature in continental US;may vary elsewhere.