protein

MAPKSP1 Protein, Human (His)

HY-P70931

10 μg;50 μg

160;450 USD

MAPKSP1 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

160;450 USD

The MAPKSP1 protein, also known as porphobilinogen deaminase (HMBS), is crucial in the heme biosynthetic pathway and catalyzes the sequential polymerization of four porphobilinogen molecules to form hydroxymethyl bixane. The process begins with the assembly of the dipyrromethane cofactor of porphobilinogen or preuroporphyrinogen. MAPKSP1 Protein, Human (His) is the recombinant human-derived MAPKSP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MAPKSP1 Protein, Human (His) is 124 a.a., with molecular weight of ~15.0 kDa.

Human

HMBS, also known as Porphobilinogen deaminase, plays a crucial role in the heme biosynthetic pathway by catalyzing the sequential polymerization of four molecules of porphobilinogen, resulting in the formation of hydroxymethylbilane, also referred to as preuroporphyrinogen. The catalytic process commences with the assembly of the dipyrromethane cofactor, formed either from two molecules of porphobilinogen or from preuroporphyrinogen, by the apoenzyme. The covalently linked cofactor serves as a primer, orchestrating the assembly of the tetrapyrrole product around it. In the final step of catalysis, the product, preuroporphyrinogen, is released, while the cofactor remains bound to the holodeaminase intact, highlighting the intricate and essential role of HMBS in the synthesis of heme.

Ragulator Complex Protein LAMTOR3; Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3; MEK-Binding Partner 1; Mp1; Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1; Mitogen-Activated Protein Kinase Scaffold Protein 1; LAMTOR3; MAP2K1IP

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 5 mM DTT, 30% Glycerol, pH 8.0.

Shipping with dry ice.