protein

Glypican-1/GPC1 Protein, Mouse (HEK293, His)

HY-P70928

10 μg;50 μg

90;250 USD

Glypican-1/GPC1 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

90;250 USD

Glypican-1 is a cell surface proteoglycan containing heparan sulfate that binds alpha-4 (V) collagen and aids in Schwann cell myelination. Glypican-1/GPC1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-1/GPC1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-1/GPC1 Protein, Mouse (HEK293, His) is 506 a.a., with molecular weight of ~60 kDa.

Mouse

Glypican-1 (GPC1) Protein is a cell surface proteoglycan characterized by the presence of heparan sulfate. It binds to alpha-4 (V) collagen through its heparan sulfate side chains, playing a role in Schwann cell myelination. Additionally, GPC1 may act as a catalyst, enhancing the conversion rate of prion protein PRPN(C) to PRNP(Sc) by associating with both forms of PRPN through its heparan sulfate side chains, facilitating their interaction and targeting them to lipid rafts. GPC1 is essential for proper skeletal muscle differentiation, as it sequesters FGF2 in lipid rafts, preventing its binding to receptors (FGFRs) and inhibiting FGF-mediated signaling. Moreover, GPC1 exhibits the ability to bind Cu(2+) or Zn(2+) ions.

Glypican-1; Gpc1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.