protein

GABARAPL1/GEC-1 Protein, Human (His)

HY-P70913

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

67;115;320;540;1200;1700 USD

GABARAPL1/GEC-1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

67;115;320;540;1200;1700 USD

GABARAPL1/GEC-1 is a multifunctional ubiquitin-like modifier that contributes to cell surface expression of kappa-type opioid receptors and contributes to autophagy, shaping autophagosome vacuoles.Unlike LC3, which is involved in phagophore elongation, the GABARAP/GATE-16 subfamily plays a crucial role in late autophagosome maturation.GABARAPL1/GEC-1 Protein, Human (His) is the recombinant human-derived GABARAPL1/GEC-1 protein, expressed by E.coli , with N-6*His labeled tag.

Human

GABARAPL1/GEC-1, a ubiquitin-like modifier, plays a multifaceted role in cellular processes. It enhances the cell-surface expression of kappa-type opioid receptors by facilitating their anterograde intracellular trafficking. Additionally, GABARAPL1/GEC-1 contributes to autophagy, participating in the formation of autophagosomal vacuoles. While LC3s are associated with phagophore membrane elongation, the GABARAP/GATE-16 subfamily assumes a crucial role in later stages of autophagosome maturation. Furthermore, GABARAPL1/GEC-1 collaborates with the reticulophagy receptor TEX264 to remodel subdomains of the endoplasmic reticulum into autophagosomes during nutrient stress, facilitating subsequent fusion with lysosomes for endoplasmic reticulum turnover. The protein engages in a network of interactions with various partners, including ATG13, OPRK1, RB1CC1, ULK1, TP53INP1, TP53INP2, SQSTM1, ATG3, ATG7, MAP15, TECPR2, TBC1D5, MAPK15, TRIM5, MEFV, TRIM21, WDFY3, UBA5, KBTBD6, KBTBD7, RETREG1, RETREG2, RETREG3, TEX264, and IRGM, underscoring its significance in cellular homeostasis and autophagic processes.

Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1; Early Estrogen-Regulated Protein; GABA(A) Receptor-Associated Protein-Like 1; Glandular Epithelial Cell Protein 1; GEC-1; GABARAPL1; GEC1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of sterile 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

Room temperature in continental US; may vary elsewhere.