protein

Kallikrein-6 Protein, Human (HEK293, His)

HY-P70887

10 μg;50 μg

170;510 USD

Kallikrein-6 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

170;510 USD

Kallikrein-6 is a serine protease that exhibits substrate preference and activity against different substrates. It degrades alpha-synuclein, plays a role in synucleinopathies, and may regulate axonal growth after spinal cord injury. Kallikrein-6 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-6 protein, expressed by HEK 293 , with C-6*His labeled tag.

Human

Kallikrein-6, a serine protease, displays a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. It exhibits activity against diverse substrates, including amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. Notably, Kallikrein-6 degrades alpha-synuclein, preventing its polymerization and suggesting a potential involvement in the pathogenesis of Parkinson's disease and other synucleinopathies. Additionally, it may play a role in regulating axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody demonstrate reduced migration, indicating a potential role in invasion and metastasis. Kallikrein-6 is susceptible to inhibition by various serine protease inhibitors, including soybean trypsin inhibitor, benzamidine, and serpins. Furthermore, its activity is modulated by several glycosaminoglycans, such as chondroitin sulfate, dermatan sulfate, heparan sulfate, and heparin.

Kallikrein-6; Neurosin; Protease M; SP59; Serine Protease 18; Serine Protease 9; Zyme; KLK6; PRSS18; PRSS9

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 5 mM HCl, 150 mM NaCl.

Shipping with dry ice