protein

GPIHBP1 Protein, Human (HEK293, Fc)

HY-P70873

10 μg;50 μg

100;300 USD

GPIHBP1 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

100;300 USD

The GPIHBP1 protein mediates lipid metabolism by transporting lipoprotein lipase LPL, anchoring it in capillaries, and preventing loss of activity. It has a crucial role in chylomicron lipolysis, triglyceride metabolism, and overall lipid homeostasis. GPIHBP1 Protein, Human (HEK293, Fc) is the recombinant human-derived GPIHBP1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GPIHBP1 Protein, Human (HEK293, Fc) is 130 a.a., with molecular weight of 50-65 kDa.

Human

GPIHBP1 Protein serves as a pivotal mediator in lipid metabolism by facilitating the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchoring LPL on the endothelial cell surface within the blood capillary lumen. In this capacity, GPIHBP1 protects LPL against loss of activity and ANGPTL4-mediated unfolding, playing a crucial role in the lipolytic processing of chylomicrons by LPL, triglyceride metabolism, and overall lipid homeostasis. The protein exhibits the ability to bind chylomicrons and phospholipid particles containing APOA5, contributing to its role in lipoprotein interactions. Furthermore, GPIHBP1 binds high-density lipoprotein (HDL), suggesting a role in the uptake of lipids from HDL. The protein exhibits a predominantly monomeric state but can also form homodimers and homooligomers. Its interaction with LPL occurs with a 1:1 stoichiometry, underlining the precision of its involvement in lipid processing. GPIHBP1's intricate network of interactions, including those with HDL and APOA5, emphasizes its significance in orchestrating lipid transport and maintaining lipid homeostasis within the vasculature.

glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein1; GPI anchored high density lipoprotein binding protein 1; GPI-Anchored HDL-Binding Protein 1; GPIHBP1; GPI-HBP1; GPI-HBP1LOC338328; HBP1; High density lipoprotein-binding protein 1; H

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.