product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
Glypican-3/GPC3 Protein, Mouse (HEK293, His)
catalog :
HY-P70872
quantity :
10 μg;50 μg
price :
70;180 USD
more info or order :
product information
Catalog Number :
HY-P70872
Product Name :
Glypican-3/GPC3 Protein, Mouse (HEK293, His)
Product Type :
proteins
Host Species :
HEK293
Size :
10 μg;50 μg
List Price :
70;180 USD
Product Description :
GPC3 is a cell surface proteoglycan that regulates Hedgehog and Wnt signaling. Glypican-3/GPC3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Mouse (HEK293, His) is 533 a.a., with molecular weight of 40 & 72-150 kDa, respectively.
SpeciesSummary :
Mouse
Background :
Glypican-3 (GPC3) Protein, a cell surface proteoglycan, intricately regulates signaling pathways crucial for developmental processes. It negatively modulates the hedgehog signaling pathway by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins, leading to complex internalization and subsequent lysosomal degradation. Conversely, GPC3 exerts positive regulation on both canonical and non-canonical Wnt signaling pathways. In the canonical Wnt pathway, it binds to the Wnt receptor Frizzled, enhancing the interaction between Frizzled and Wnt ligands. GPC3 also binds to CD81, reducing the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Additionally, GPC3 inhibits the dipeptidyl peptidase activity of DPP4. Functionally, GPC3 plays essential roles in limb patterning, skeletal development, renal branching morphogenesis, coronary vascular development, and cell movements during gastrulation. This multifaceted protein exists as a heterodimer formed by disulfide linkage and interacts with various molecules, including DPP4, FGF2, WNT5A, WNT3A, WNT7B, hedgehog proteins SHH and IHH, and Wnt receptors FZD4, FZD7, and FZD8, highlighting its central role in developmental processes.
ALTnames :
Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA